If you print on white card with black fold and cut lines, then I recommend you spray a gray or dark color coat of primer on it first, then a coat of flat white, then the finishing coats of color. The print and fold lines tend to show through if you try to paint the colors straight on the printed card or paper.
I no longer print black for the line color, I use a light gray so it is less obtrusive. Sometimes I can go straight to the flat white as a primer this way.
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